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Artículo
Genetic and Epigenetic Regulation in Nonalcoholic Fatty Liver Disease (NAFLD)
Campo, José Antonio del; Gallego Durán, Rocío; Gallego, Paloma; Grande, Lourdes (MDPI AG, 2018-03-19)Genetics and epigenetics play a key role in the development of several diseases, including nonalcoholic fatty liver disease ...
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Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells
Rodríguez Hernández, María A.; González, Raúl; Rosa, Ángel J. de la; Gallego, Paloma; Ordóñez, Raquel; Navarro Villarán, Elena; Contreras Bernal, Laura; Rodríguez Arribas, M.; Cruz Díaz, Jesús de la (Wiley-Blackwell, 2018)Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular ...
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Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype
Rojas, Ángela; Gallego, Paloma; Gil Gómez, Antonio; Muñoz Hernández, Rocío; Martín, Lourdes; Gallego Durán, Rocío; García Valdecasas, Marta; Campo, José A. del; Bautista Palomas, Juan Dionisio; Romero Gómez, Manuel (Elsevier, 2018)Background & aims. G-allele of PNPLA3 (rs738409) favours triglycerides accumulation and steatosis. In this study, we ...
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Piperazine-derived small molecules as potential Flaviviridae NS3 protease inhibitors. In vitro antiviral activity evaluation against Zika and Dengue viruses
García Lozano, María del Rosario; Dragoni, Filippo; Gallego, Paloma; Mazzotta, Sarah; López Gómez, Alejandro; Boccuto, Adele; Martínez-Cortés, Carlos; Rodríguez-Martínez, Alejandro; Pérez-Sánchez, Horacio; Vega Pérez, José Manuel; Del Campo, José Antonio; Vicenti, Ilaria; Vega Holm, Margarita; Iglesias Guerra, Fernando (Elsevier, 2023)Since 2011 Direct Acting antivirals (DAAs) drugs targeting different non-structural (NS) viral proteins (NS3, NS5A or NS5B ...
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Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy
Campo, José Antonio del; García Valdecasas, Marta; Gil Gómez, Antonio; Rojas Alvarez-Ossorio, M. Angeles; Gallego, Paloma; Ampuero Herrojo, Javier; Gallego Durán, Rocío; Pastor, Helena; Grande, Lourdes; Padillo Ruiz, Francisco Javier; Muntané Relat, Jordi; Romero Gómez, Manuel (2018-01-31)Hepatitis C virus (HCV) infection has been related to increased risk of development of hepa tocellular carcinoma (HCC) ...